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Biol Pharm Bull. 2005 Sep;28(9):1615-20. Effects of SKI306X on arachidonate metabolism and other inflammatory mediators
Kim JH, Ryu KH, Jung KW, Han CK, Kwak WJ, Cho YB. Life Science Research Center, SK Chemicals, Suwon-Si, Kyungki-Do, Korea.

SKI306X was previously reported to have good anti-inflammatory and analgesic efficacy in various studies. To determine its mode of action, an investigation was carried out for some representative mediators. Arachidonic acid metabolism and its products are particularly important in inflammation and pain. The pro-inflammatory cytokines, especially interleukin-1 (IL-1) and tumor necrosis factor (TNF-alpha), and induced nitric oxide (NO) appear to be most involved in the inflammatory process such as osteoarthritis (OA). Thus SKI306X was tested to determine the effects on enzymes related to arachidonic acid metabolism and the release or synthesis of inflammatory mediators. SKI306X did inhibit the expression of cyclooxygenase-2 (COX-2) enzyme without affecting COX-1 and COX-2 activity. Leukotriene B4 (LTB4) production also was inhibited by SKI306X (IC50 = 98.7+/-4.26 microg/ml). SKI306X inhibited significantly TNF-alpha release (IC50 = 97.6+/-17.8 microg/ml) and NO production (IC50 = 280+/-17.8 microg/ml). But IL-1alpha release was not attenuated by SKI306X. This study suggests that inhibition of these mediators by SKI306X may be one of the mechanisms responsible for its anti-inflammatory effects. PMID: 16141526 [PubMed - indexed for MEDLINE]




Systemic Analysis:

Prevention of Peripheral Organ Damage in Hashimoto’s Thyroiditis: Synephrine

Synephrine binds with the Beta 3 cell receptors to increase the rate at which fat is released from body stores (lipolysis), along with increasing the metabolic rate. Weight loss stems from the combination of lipolysis (releasing fat from body stores) and thermogenesis (increasing the metabolic rate). Synephrine increases Resting Energy expenditure by 8.2% over 4 hours. Stimulation of the beta-3 receptor site elicits the breakdown of lipolysis (fat). Simultaniously, this stimulation increases the metabolic rate (thermogenesis), which burns calories. In an study on pig it was found that eight-day administration of synephrine had beneficial hemodynamic effects in two models of portal hypertensive rats.5 Citrus aurantium known to have antihypercholesterolemic activity (prevents elevation of serum cholesterol level) in humans and animals. This effect is attributed to the constituent pectin in Citrus aurantium.6 The leaf and flower of bitter orange are used for symptoms of neurotonic disorders in both children and adults and found to be useful.7,8







Statistical Analysis



Regulatory Writing

Muscarinic Antagonist NCK5126: A Promising Alternative to the Conventional Therapy for Overactive Bladder


In the management of OAB, pharmacotherapy coupled with behavioural training is the standardized first-line of treatment.2-4 Among the various drugs, traditional anticholinergics are still considered to be the “gold standard” for the treatment of OAB. Oral oxybutynin has been the most widely prescribed drug for nearly 30 years. In recent years, a number of alternatives have been introduced such as, tolterodine, tropsium, solifenacin and darifenacin. As compared to the immediate release formulations, extended release dosing maintains steady plasma concentrations and improves tolerability.8-10 Despite this, anticholinergic side-effects remain the major limiting factor in the current drug therapy and the patient compliance.11,12 Rational Formulations



Rational Formulations


Rational Formulations


Health Consultancy


Current Medical Opinion

Evolving Issues in Pain Management

Pharmacological therapy at present cannot intervene at all levels. Then there are considerations regarding their side effects and interactions of the multitude of medications that would be required to achieve such an effect. This is where complementary and alternative medicine comes in. Acupuncture, biofeedback-relaxation, manipulation, physical therapy/massage, herbal substances, and hypnosis are some are the more popular and effective modalities employed. Among these acupuncture is believed to release the natural opium-like substances in the body and make pain more tolerable. Biofeedback and Relaxation techniques aim to exert voluntary control over the autonomous components of the nervous system. Through practice and patience, the person learns to curb the activity of the sympathetic nervous system that hyper-sensitizes the pain receptors and pathways. Cognitive and Behavioral therapy train the individual to choose the response to a particular life situation, preventing the development of secondary problems like depression and anxiety.

A variety of studies, in varied settings have shown that pain management is not about choosing one modality over another, but rather implementing a comprehensive plan that introduces appropriate therapy at appropriate points in pain management.


In-depth Review

Hashimoto’s thyroiditis

Hashimoto’s thyroiditis (inflammation of thyroid gland) is the most common cause of hypothyroidism in populations with adequate intake of iodine. Hashimoto’s disease is an autoimmune thyroid disorder, wherein the person’s immune system produces auto antibodies against its own thyroid cells and its constituents. .

These auto-antibodies are produced against an enzyme (thyroid peroxidase (TPO) and a protein (thyroglobulin-Tg) involved in thyroxine synthesis. The thyroid gland becomes infiltrated with immune cells, namely B-cells and T-cells, which lead to the self-destruction (apoptosis) of the thyroid cells (follicular epithelial cells).



Health Communications

Presentation

Presentation


Print Media

Magazine Article


MYTHS ABOUT ACNE


Summary
Various myths abound regarding acne. For myths surrounding acne this article is an indepth study. It dispels these myths with the actual truth behind these myths.

Introduction
This article reviews the evidence for common lay and medical myths about acne. Human perceptions have commonly misinterpreted many observations related to the causes, the exacerbating factors and the treatment of acne. Myths are prevalent not only
among patients but also among the medical fraternity. Recent research publications have tried to identify many such beliefs in an effort to dispel them.

Myth: Tanning clears acne…
Truth: A tan can only mask acne temporarily by increasing the melanin pigment in the
skin. In the long run, tanning can in fact make the skin dry and irritated leading to more
breakouts in the future. Documented evidence shows that exposure to UV light worsens
comedonal lesions. Also, over exposure to the sun carries the risk of developing
premature ageing and skin cancers.

Myth: Diet (Chocolate and fatty foods increase acne):

Truth: Every person is different genetically. Studies have found that no food is
specifically known to cause acne. Although some people may notice breakouts soon after
taking a particular food, this may not be the case with another person for the same food.
Diets that raise blood sugar levels rapidly, thus stimulating high levels of insulin, can
result in a hormonal imbalance facilitating the development of acne. This might also be
the reason why excess junk food is responsible for increase in acne lesions seen in
stressful periods like pre-examination university students."

Newsletter


Web Content

Search Engine Optimization

Primary Keyword: hearing impaired phones Tier 1: hearing impaired phone Variations: hearing, impaired, phone, phones Notes to writer: No Tier-2 keywords required for press release articles

Hearing Impaired Phones- Break The Silence! People with their sense of hearing impaired are usually pushed into a world of prevailing silence. Having lost the sense of hearing, the affected ones are vulnerable to discrimination and social segregation. It was till a few years back, when people used to live their whole life with this disability; but no more it happens, thanks to the hearing impaired phones.

Enjoy the sounds again…
The individual who uses hearing impaired phone experiences a tremendous difference as he starts enjoying the voices he hears. The phones help you relate to the outside world and be a part of it. The phonic devices for the hearing impaired are a boon to them that helps them live a normal life.


Feeder Articles


"Psoriasis: A Brief Review

Definition:
  • A chronic non contagious skin disorder that most commonly appears as well demarcated inflamed, edematous pink skin lesions covered with silvery white scales.

Incidence
  • Elbows, knees and scalp are commonly affected.
  • Lower back, face, palms, and soles of the feet, fingernails, toenails, genitals, and inside the mouth can also get affected.
  • Apart from the skin, joints can also are affected in 10% of cases.
  • 2-2.6% of the US population is affected. 150,000 to 260,000 new cases occur annually.
  • One of the commonest skin diseases in Britain affecting 2% of the population.
  • Incidence is dependant on genetic heritage and climate.
  • Over 50% of patients with psoriasis report a positive family history, and a 65 to 72% concordance among twins has been reported in twin studies.
  • Less common in the tropics and in dark skinned individuals.
  • Commonest time of onset is the adolescent period.
  • Psoriasis is more common in whites.
  • Psoriasis is slightly more common in women.
  • Median age of onset is 28 years.

Types of Psoriasis
  • Plaque Psoriasis: Most common form of the disease characterized by raised inflamed lesions covered with a silvery white scale. Most common on the knees, elbows, scalp and trunk.
  • Guttate Psoriasis: Appears as small red spots on the skin of the trunk, arms and legs usually occur after a respiratory infection.
  • Inverse Psoriasis: Occurs in armpits, groin and skin folds under the breast characterized by smooth inflamed lesions without scaling.
  • Pustular Psoriasis: White blisters surrounded by red skin
  • Erythrodermic Psoriasis: Intense redness over large areas
  • Psoratic arthritis: Causes pain, stiffness and swelling in and around the joints.
  • Psoriasis of nails causes pits on the nails, which may become yellow and separate from the nail bed.
  • Oral psoriasis produces white or intense inflammatory red lesions on the oral mucosa increasing in severity day by day."

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